Líneas de Investigación

1. "Mecanismos moleculares de Mycobacterium tuberculosis (a través  de WhiB3) para persistir en el pulmón humano"

2. Búsqueda de compuestos con actividad bactericida hacia Mycobacterium tuberculosis"

 Artículos Publicados

1.    Juárez E, Vázquez-Pérez JA, Carreto-Binaghi LE, Martínez-Sanabria CA, Salgado-Cantú MG, Sarabia C, Herrera MT, Guzmán-Beltrán S, Gutiérrez-González LH, González Y. COVID-19 extracellular vesicles display heterogeneity based on viral and host RNA expression: implications for host immune response. J Leukoc Biol. 2025 Feb 13;117(2):qiae212. doi:10.1093/jleuko/qiae212.

2.    Salgado-Cantú MG, Gutiérrez-González LH, Guzmán-Beltrán S, Herrera MT, Sarabia C, González Y. Impact of Mycobacterium tuberculosis H37Rv Infection on Extracellular Vesicle Cargo in Macrophages: Implications for Host-Pathogen Interaction. Microorganisms. 2024 Nov 23;12(12):2405. doi: 10.3390/microorganisms12122405.

3.    Guzmán-Beltrán S., Juárez E., Cruz-Muñoz B.L., Páez-Cisneros C.A., Sarabia C. y González Y. Bactericidal Permeability-Increasing Protein (BPI) Inhibits Mycobacterium tuberculosis Growth. Biomolecules. 2024, 14(4), 475. doi.org/10.3390/biom14040475.

4.    Reyes-Lazcano ME, Dora Rosete-Olvera y *Guzmán-Beltrán S., Uso de antioxidantes in pacientes con tuberculosis. 2023. NCT Neumología y Cirugía de Tórax 82(3):174-182. doi: 10.35366/116816.

5.    Guzmán-Beltrán S., Luna-Villagómez H., Páez-Cisneros C.A., Santos-Méndez M.A., Reyes-Lazcano E. Importancia de la proteína antimicrobiana bactericida que aumenta la permeabilidad en enfermedades respiratorias. 2023. NCT Neumología y Cirugía de Tórax 82(1):29-35. DOI: 10.35366/114226

6.    Carranza C, Sartillo-Mendoza LG, Carreto-Binaghi LE, Muñoz-Torrico M, Guzmán-Beltrán S, Torres M, Gonzalez Y, Juárez E. Exploring COX-2 inhibitors in tuberculosis: A whole-blood model approach for immune response and adjunt therapy evaluation. Tuberculosis. 2023 Dec;143:102418. doi: 10.1016/j.tube.2023.102418.

7.    Carreto-Binaghi LE, Sartillo-Mendoza LG, Muñoz-Torrico M, Guzmán-Beltrán S, Carranza C, Torres M, González Y, Juárez E. Serum pro-inflammatory biomarkers associated with improvement in quality of life in pulmonary tuberculosis. Front Immunol. 2023 Sep 11;14:1241121. doi: 10.3389/fimmu.2023.1241121.

8.    Carreto-Binaghi LE, Herrera MT, Guzmán-Beltrán S, Juárez E, Sarabia C, Salgado-Cantú MG, Juarez-Carmona D, Guadarrama-Pérez C, González Y. Reduced IL-8 Secretion by NOD-like and Toll-like Receptors in Blood Cells from COVID-19 Patients. Biomedicines. 2023 Apr 3;11(4):1078. doi: 10.3390/biomedicines11041078.

9.    Barrientos OM, Langley E, González Y, Cabello C, Torres M, *Guzmán-Beltrán S. Mycobacterium tuberculosis whiB3 and lipid metabolism genes are regulated by Host Induced Oxidative Stress. 2022. Microorganisms. 11;10(9):1821. doi: 10.3390/microorganisms10091821.

10.  Herrera MT, Guzmán-Beltrán S, Bobadilla K, Santos-Mendoza MT, Flores-Valdez, Gutiérrez-González LH y González Y. 2022. Human Pulmonary Tuberculosis: Understanding the Immune Response in the Bronchoalveolar System. Biomolecules. doi:10.3390/biom12081148.

11.  Carranza C, Carreto-Binaghi LE, Guzmán-Beltrán S, Muñoz-Torrico M, Torres M, González Y, Juárez E. 2022. Sex-Dependent Differential Expression of Lipidic Mediators Associated with Inflammation Resolution in Patients with Pulmonary Tuberculosis. Biomolecules. Mar 24;12(4):490. doi: 10.3390/biom12040490.

12.  Herrera MT, Juárez E, Guzmán-Beltrán S, Torres M, Luna-Morales VA, Villalana-Alvarez LD, González Y. 2022. High Vitamin D Concentrations Restore the Ability to Express LL37 by M. tuberculosis-Infected Human Macrophages. Biomolecules. 7;12(2):268. doi: 10.3390/biom12020268.

13.  Guzmán-Beltrán S, Herrera MT, Torres M, Gonzalez Y. 2022. CD33 is downregulated by influenza virus H1N1pdm09 and induces ROS and the TNF-α, IL-1β, and IL-6 cytokines in human mononuclear cells. Braz J Microbiol. 53(1):89-97. doi: 10.1007/s42770-021-00663-4.

14.  Guadalupe Monroy-Mérida, Silvia Guzmán-Beltrán, Fernando Hernández, Teresa Santos-Mendoza y Karen Bobadilla. 2021. High Glucose Concentrations Impair the Processing and Presentation of Mycobacterium tuberculosis Antigens In Vitro. Molecules. 11(1763). doi.org/10.3390/biom11121763.

15.  Carranza C, Herrera MT, Guzmán-Beltrán S, Salgado-Cantú MG, Salido-Guadarrama I, Santiago E, Chávez-Galán L, Gutiérrez-González LH, González Y. 2021. A Dual Marker for Monitoring MDR-TB Treatment: Host-Derived miRNAs and M. tuberculosis-Derived RNA Sequences in Serum. Front Immunol. 4;12:760468. doi: 10.3389/fimmu.2021.760468.

16.  Gutiérrez-González LH, Rivas-Fuentes S, Guzmán-Beltrán S, Flores-Flores A, Rosas-García J, Santos-Mendoza T. 2021. Peptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases. Molecules. 21;26(21):6367. doi: 10.3390/molecules26216367.

17.  Guzmán-Beltrán S, Carreto-Binaghi LE, Carranza C, Torres M, Gonzalez Y, Muñoz-Torrico M, Juárez E. 2021. Oxidative Stress and Inflammatory Mediators in Exhaled Breath Condensate of Patients with Pulmonary Tuberculosis. A Pilot Study with a Biomarker Perspective. Antioxidants (Basel) 5;10(10):1572. doi: 10.3390/antiox10101572.

18.  Choreño-Parra JA, Dunlap MD, Swanson R, Jiménez-Álvarez LA, Muñoz-Torrico M, Guzmán-Beltrán S, Zúñiga J, Khader SA. 2021. CXCL17 Is Dispensable during Hypervirulent Mycobacterium tuberculosis HN878 Infection in Mice. Immunohorizons. 24;5(9):752-759. doi: 10.4049/immunohorizons.2100048.

19.  Barrientos OM, Juárez E, Gonzalez Y, Castro-Villeda DA, Torres M, Guzmán-Beltrán S. 2021. Loperamide exerts a direct bactericidal effect against M. tuberculosis, M. bovis, M. terrae and M. smegmatis. Lett Appl Microbiol. 72(3):351-356. doi: 10.1111/lam.13432.

20.  Carreto-Binaghi LE, González Y, Guzmán-Beltrán S. 2021. Enfermedad pulmonar causada por micobacterias no tuberculosas: diagnóstico, tratamiento y mecanismos de resistencia a los antimicrobianos. NCT Neumología y Cirugía de Tórax. 80(2). 142-153. doi: 10.35366/100997

21.  Guzmán Beltrán S, Sánchez Morales J, González Canto A, Escalona Montaño A, Torres Guerrero H. 2021. Human serum proteins bind to Sporothrix schenckii conidia with differential effects on phagocytosis. Braz J Microbiol. 52(1):33-39. doi: 10.1007/s42770-020-00276-3. 

22.  González-Torres M, Guzmán-Beltrán S, Mata-Gómez MA, Leyva-Gómez G, Velasquillo C, Zúñiga-Ramos J, Vargas-Muñoz S, Cortes H, y Rodríguez-Talavera R. 2019. Radiation-induced PEGylated Ethambutol has low antimycobacterial activity in vitro. Biointerface Research in Applied Chemistry. 11;2(2021) 8884-8894. https://doi.org/10.33263/BRIAC112. 88848894.

23.  Carreto-Binaghi LE, Juárez E, Guzmán-Beltrán S, Herrera MT, Torres M, Alejandre A, Martínez-Orozco JA, Becerril-Vargas E, Gonzalez Y. 2020. Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed? J Immunol Res. 14;2020:8235149. doi: 10.1155/2020/8235149.

24.  Guerra-De-Blas PDC, Bobadilla-Del-Valle M, Sada-Ovalle I, Estrada-García I, Torres-González P, López-Saavedra A, Guzmán-Beltrán S, Ponce-de-León A, Sifuentes-Osornio J. 2019. Simvastatin Enhances the Immune Response Against Mycobacterium tuberculosis. Front Microbiol. 20;10:2097. doi: 10.3389/fmicb.2019.02097.

25.  González-Torres M, Guzmán-Beltrán S, Mata-Gómez MA, González-Valdez J, Leyva-Gómez G, Melgarejo-Ramírez Y,  Brostowf W, Velasquillo C, Zúñiga-Ramos J, Rodríguez-Talavera R. 2019. Synthesis, characterization, and in vitro evaluation of gamma radiation induced PEGylated isoniazid. Electronic Journal of Biotechnology. 41(2019) 81-87.

26.  Ruiz A, Guzmán-Beltrán S, Carreto-Binaghi LE, Gonzalez Y, Juárez E. 2019. DNA from virulent M. tuberculosis induces TNF-α production and autophagy in M1 polarized macrophages. Microb Pathog. 132:166-177. doi: 10.1016/j.micpath.2019.04.041.

27.  Hernández-Sánchez F, Guzmán-Beltrán S, Herrera MT, Gonzalez Y, Salgado M, Fabian G, Torres M. 2017. High glucose induces O-GlcNAc glycosylation of the vitamin D receptor (VDR) in THP1 cells and in human macrophages derived from monocytes. Cell Biol Int. 41(9):1065-1074. doi: 10.1002/cbin.10827.

28.  Guzmán-Beltrán S, Torres M, Arellano M, Juárez E. 2017. Human macrophages chronically exposed to LPS can be reactivated by stimulation with MDP to acquire an antimicrobial phenotype. Cell Immunol. 315:45-55. doi: 10.1016/j.cellimm.2017.02.004.

29.  Guzmán-Beltrán S, Rubio-Badillo MÁ, Juárez E, Hernández-Sánchez F, Torres M. 2016. Nordihydroguaiaretic acid (NDGA) and α-mangostin inhibit the growth of Mycobacterium tuberculosis by inducing autophagy. Int Immunopharmacol. 31:149-57. doi: 10.1016/j.intimp.2015.12.027.

30.  González-Reyes S, Guzmán-Beltrán S, Medina-Campos ON, Pedraza-Chaverri J. 2013. Curcumin pretreatment induces Nrf2 and an antioxidant response and prevents hemin-induced toxicity in primary cultures of cerebellar granule neurons of rats. Oxid Med Cell Longev. doi: 10.1155/2013/801418.

31.  Herrera MT, Gonzalez Y, Juárez E, Hernández-Sánchez F, Carranza C, Sarabia C, Guzman-Beltran S, Manjarrez ME, Muñoz-Torrico M, Garcia-Garcia L, Sada E, Torres M. 2013. Humoral and cellular responses to a non-adjuvanted monovalent H1N1 pandemic influenza vaccine in hospital employees. BMC Infect Dis. 15;13:544. doi: 10.1186/1471-2334-13-544.

32.  Guzmán-Beltrán S, Pedraza-Chaverri J, Gonzalez-Reyes S, Hernández-Sánchez F, Juarez-Figueroa UE, Gonzalez Y, Bobadilla K, Torres M. 2013. Nordihydroguaiaretic acid attenuates the oxidative stress-induced decrease of CD33 expression in human monocytes. Oxid Med Cell Longev, doi: 10.1155/2013/375893.

33.  Guzman-Beltran S, Perez-Torres A, Coronel-Cruz C, Torres-Guerrero H. 2012. Phagocytic receptors on macrophages distinguish between different Sporothrix schenckii morphotypes. Microbes Infect. 14(12):1093-101. doi: 10.1016/j.micinf.2012.06.001.

34.  Gonzalez Y, Herrera MT, Soldevila G, Garcia-Garcia L, Fabián G, Pérez-Armendariz EM, Bobadilla K, Guzmán-Beltrán S, Sada E, Torres M. 2012. High glucose concentrations induce TNF-α production through the down-regulation of CD33 in primary human monocytes. BMC Immunol.14;13:19. doi: 10.1186/1471-2172-13-19.

35.  Cárdenas-Rodríguez N., Guzmán-Beltrán S., Medina-Campos ON., Orozco-Ibarra M., Massieu L., Pedraza-Chaverri J. 2009. The effect of nordihydroguaiaretic acid on iodoacetate-induced toxicity in cultured neurons. Journal of Biochemical and Molecular Toxicology. 23 (2): 137-142.

36.  González-Reyes S, Orozco-Ibarra M, Guzmán-Beltrán S, Molina-Jijón E, Massieu L, Pedraza-Chaverri J. 2009. Neuroprotective role of heme-oxygenase 1 against iodoacetate-induced toxicity in rat cerebellar granule neurons: Role of bilirubin. Free Radical Research. 43(3):214-23.

37.  Guzmán-Beltrán S, Espada S, Orozco-Ibarra M, Pedraza-Chaverri J, Cuadrado A. 2008. Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/HO-1 and protects cerebellar granule neurons against oxidative stress. Neuroscience Letters. 12; 447 (2-3):167-71.

38.  Guzmán-Beltrán S., Orozco-Ibarra M., González-Cuahutencos O., Victoria-Mares S., Merchand-Reyes G., Medina-Campos O. N. y Pedraza-Chaverri J. 2008.  Neuroprotective effect and reactive oxygen species scavenging capacity of Mangosteen pericarp extract in cultured neurons. Current topics in Nutraceutical Research. 6:3: 149-157.

39.  Guzmán S., Carmona A., Escalante L., Imriskova I, López R., Rodríguez-Sanoja R., Ruiz B., Servín-González L., Sánchez S., Langley E. 2005. Pleiotropic effect of the SCO2127 gene on the glucose uptake, glucose kinase activity and carbon catabolite repression in Streptomyces peucetius var. caesius. Microbiology. 151: 1717-1723.

40.  Guzmán S., Ramos I., Moreno E., Ruiz B., Rodríguez-Sanoja R., Escalante L., Langley E., Sánchez S. 2005. Sugar uptake and sensitivity to carbon catabolite repression in Streptomyces peucetius var. caesius. Applied Microbiology and Biotechnology. 69(29): 200-206.

41.  Imriskova I., Arreguin-Espinosa R., Guzmán S., Rodríguez-Sanoja R., Langley E., Sánchez S. 2005. Biochemical characterization of the glucose kinase from Streptomyces coelicolor compared to Streptomyces peucetius var. caesius Research in Microbiology. 153 (3): 361-366.

42. Ramos I., Guzmán S., Escalante L., Imriskova I., Rodríguez-Sanoja R., Sánchez S., Langley E. 2004. The glucose kinase alone cannot be responsible for source regulation in Streptomyces peucetius var. caesius. Research in Microbiology. 155: 267-274.

 Capítulos de Libros

1. Juárez, E., Carreto-Binaghi, L. E., Guzmán-Beltrán, S., Muñoz-Torrico, M., & González, Y. (2024). Features of Pulmonary Tuberculosis (TB): Linking Biomarkers and Quality of Life Measures. In Handbook of the Behavior and Psychology of Disease (pp. 1-23). Cham: Springer International Publishing. doi.org/10.1007/978-3-031-32046-0_175-1

2. Gonzalez Y, Guzmán-Beltrán S, Carreto-Binaghi LE, Juárez E. Translational research for therapy against tuberculosis. Nanotechnology Based Approaches for Tuberculosis Treatment. Elsevier Sience; 2020; pp 53–73. ISBN: 978-0-12-819811-7. DOI: 10.1016/B978-0-12-819811-7.00004-7.

3. Guzman-Beltrán, S., Sánchez, F. H., & Barrientos, O. M. Translational research for therapy against tuberculosis. Natural Products with Antimicrobial Activity for Mycobacterium tuberculosis. Anti-infective Research and Development: Updates on Infection Mechanisms and Treatments, 2, 25-55. Bentham Science Publishers. 2020. ISBN: 978-0-12-819811-7.

Distinciones

Miembro del Sistema Nacional de Investigadores “SNI Nivel I”. Periodo: 2022-2025

Nombramiento

Investigador en Ciencias Médicas “D”

Dirección Laboral

Secretaria de Salud: Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”.

Formación Académica

 Estancia Posdoctoral

Programa de Becas Posdoctorales de la UNAM

Facultad de Química, UNAM.

Asesor: Dr. José Pedraza-Chaverri

Periodo: Agosto del 2006- julio 2008

Doctorado

 Doctora en Ciencias (Bioquímicas), Instituto de Investigaciones Biomédicas, UNAM.

Tutor principal: Dr. Sergio Sánchez Esquivel.

Obtención del grado: Marzo de 2005

Licenciatura

Bióloga. Facultad de Ciencias, UNAM.

Tutor principal: Dra. Celia Barrena González

Obtención del grado: Enero de 1999